A research team comprising Assistant Professor Zhao Ziqing, Winston from the Department of Chemistry and Centre for BioImaging Sciences, NUS, in collaboration with scientists from Peking University and University of Technology Sydney, have discovered a pattern that governs the propagation of deoxyribonucleic acid (DNA) replication in space and time by directly visualising the process in single human cells with sub-diffraction-limit resolution. They have performed the first quantitative characterisation of the spatio-temporal organisation, morphology, and in situ epigenetic signatures of individual RFi in single human cells at super-resolution (~20 nm laterally). Assistant Professor Zhao, who co-led the study said, “Our findings shed critical mechanistic insights into the role local epigenetic environment plays in coordinating DNA replication across the genome. More broadly, these findings could have fundamental implications for our understanding of how multi-scale chromatin architecture controls the organisation and dynamics of other intranuclear processes in space and time.” Read more about their new discovery here.
