LEE Hian Kee
Emeritus Professor
Special Volunteer, National Institutes of Health, Bethesda, USA, 1991/1992; Ph.D., University of Canterbury, 1982; B.Sc., University of Canterbury, 1978.
Contact Information:
Email: chmleehk@nus.edu.sg
Research
Recognition and Achievements
- NUS Provost’s Term Chair Professor 2011-2014
- Editor, Journal of Chromatography A, 2010 – current; Editorial Board, Journal of Chromatography A, 2004 – 2010
- Member, Editorial Boards, Chemical Data Collections, 2015 – current; Talanta, 2017 – current; International Journal of Environmental Analytical Chemistry, 2017 – current
- Editor, Analytica Chimica Acta, 2005 – 2011; Editorial Advisor, Analytica Chimica Acta, 2003 – 2005
- Member, Advisory Board, Analytical Sciences, 2004 – current
- Member, Editorial Advisory Boards, LC·GC Asia Pacific, 2006 – current; LC·GC Europe, 2008 – current
- Member, International Editorial Advisory Board, Journal of the Chinese Chemical Society, 2011 – current
- Member, Editorial Advisory Board, Journal of Advanced Research, 2010 – current
- Member, International Advisory Board, Analyst, 1997 – 2008
- NUS Outstanding Researcher Award, 2006
- NUS Faculty of Science Outstanding Scientist Award, 2009
- Federation of Asian Chemical Societies Foundation Award, 2009
- Hyflux-Singapore National Institute of Chemistry Award in Environmental Chemistry, 2013
- The Analytical Scientist Power List: “100 Most Influential People in the Analytical Sciences,” 2013, 2015
- Visiting Professor, 2019-2020, Kyushu University, Japan; Visiting Professor 2018-2020, University Terengganu Malaysia
- Elected Fellow: Royal Society of Chemistry, Singapore National Academy of Science, Academy of Sciences Malaysia
Research Interests
Our main research focus is on the development and application of miniaturized, solvent-minimized sample preparation procedures in combination with chromatography. A primary objective is to apply these methods particularly to the analysis of contaminants of emerging concern. Our present interest includes the development of seamless, integrated automated analytical platforms for water quality monitoring applications. Lately, we have been working on smartphone-based analytical platforms.
Research Highlight
Ref: Magnetic Three-Phase Single-Drop Microextraction for Rapid Amplification of the Signals of DNA and microRNA Analysis, Anal. Chem. 2020, 92, 12290-12296.
This paper describes the use of magnetic branched DNA/Fe3O4 networks in combination with single-drop microextraction for the quantification of nucleic acids. To show its capability, the approach was applied successfully to determine miRNA-122 and HBV-T in serum samples from hepatocellular carcinoma patients.
Representative Publications
- Hou, W., Mao, W., Yu, D., Pan, Y., Shen, W., Zhang, J., Kong, D., Zang, L., Dai, H., Yang, F., Lee, H.K. & Tang, S. Photo-Crosslinked Hydrogel as a Sensing Platform for Sensitive Detection of Free Bilirubin in Urine Samples. Sens. Actuators B: Chem. 2024, 411, 135663.
- Zhang, X., Zhou, X., Chen, H., Gao, Xi., Zhou, Y., Lee, H.K. & Huang, Z. Changes in Concentrations of Polyfluoroalkyl Substances in Human Milk over Lactation Time and Effects of Maternal Exposure via Analysis of Matched Samples. Environ. Sci. Technol. 2024, 58, 4115-4126.
- Aramesh, N., Bagheri, A.R., Zhang, Z., Yadollahi, B. & Lee, H.K. Polyoxometalate-Based Materials Against Environmental Pollutants: A Review. Coord. Chem. Rev. 2024, 507, 215767.
- Song, C., Ma, Z., Zhang, M., Liu, C., Tang, S., Zhang, J., Song, J. Yu, H., Lee, H.K.& Shen, W. Multiplex Detection of Single Nucleotide Polymorphisms by Liquid Chromatography for Non-Small Cell Lung Cancer Staging. Anal. Chem. 2024, 96, 1054-1063.
- Zhuang, Y., Tang, S., Shen, W., Yang, F. & Lee, H.K. Recent Progress of Graphene Aerogel as Sorbent in Solid-Phase Extraction: A Review. Trends Anal. Chem. 2023, 168, 117352 (Invited)
- Zhou, Y., Lin, X., Xing, Y., Zhang, X., Lee, H.K., Huang, Z. Per- and Polyfluoroalkyl Substances in Personal Hygiene Products: The Implications for Human Exposure and Emission to the Environment. Environ. Sci. Technol. 2023, 57, 8484-8495.
- Yang, Y., Xu, F., Chen, J., Tao, C., Li, Y., Chen, Q., Tang, S., Lee, H.K. & Shen, W. Artificial Intelligence-Assisted Smartphone-Based Sensing for Bioanalytical Applications: A Review. Biosens. Bioelectron. 2023, 229, 115233.
- Kuang, J., Wang, L., Yin, Y., Shen, W., Liu, C., Lee, H.K. & Tang, S. Spatial Confinement of Single-Drop System to Enhance Aggregation-Induced Emission for Detection of MicroRNAs. Anal. Chem. 2023, 95, 5346-5353.
- Song, C., Liu, C., Chen, J., Ma, Z., Tang, S., Pan, R., Suo, Xi., Yan, Z., Lee, H.K. & Shen, W. Self-Generation of Distinguishable Fluorescent Probes via One-Pot Process for Multiple MicroRNA Detection by Liquid Chromatography. Anal. Chem. 2023, 95, 4113-4121.
- Huang, Z., Liu, P., Chen, H., Lin, X., Zhou, Y., Xing, Y. & Lee, H.K. Electrospun Fluorinated Carbon Nanotubes/Silk Fibroin Composite Nanofibers for the Analysis of Perfluoroalkyl and Polyfluoroalkyl Substances. J. Hazard. Mater. 2023, 448, 130955.
