ZHAO Yu

ZHAO Yu

Professor, Assistant Dean (Graduate Studies)

Postdoc., MIT, 2008-2011; Ph.D., Boston college, 2008; B.S., Peking University, 2002.

Contact Information:

Office: S9-13-01E

Tel: (65)-6516-7964

Fax: (65)-6779-1691

Email: zhaoyu@nus.edu.sg


Research

ORCID: 0000-0002-2944-1315
ResearcherID: J-1712-2014

 

Recognition and Achievements

 

Research Interests

Research interests of our lab lie in the discovery and development of efficient, selective as well as economical catalytic methods for chemical synthesis, with an emphasis on asymmetric catalysis. Application of the new methods toward the synthesis of molecules with a complex structure and/or useful functions will serve as a testament of the efficacy of the method development. Ultimately, the goal is to provide new chemical tools to bear on contemporary problems in the applied areas such as pharmaceuticals, chemical biology and material science.

 

Research Highlight

We have established a one-step synthesis of valuable enantioenriched six-membered N-heterocycles from readily available racemic 1,5-diols. Key to the success is the development of new iridacycle catalysts that enable an efficient redox-neutral construction of two C-N bonds between diols and amines in an enantioconvergent fashion. Mechanistic studies identified an intriguing preferential oxidation of secondary vs. primary alcohol in the diol substrate by the iridacycle catalyst, which set a challenging intermolecular amination of aryl-alkyl substituted alcohol as the enantiodetermining step for this catalytic N-heterocycle synthesis. (J. Am. Chem. Soc. 10.1021/jacs.4c12466).

 

Teaching Contributions AY2024/2025

 

Representative Publications