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X-WR-CALDESC:Events for NUS Chemistry
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BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20210326T090000
DTEND;TZID=Asia/Singapore:20210326T130000
DTSTAMP:20260423T005943
CREATED:20210305T004957Z
LAST-MODIFIED:20210305T005547Z
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SUMMARY:Retirement Symposium: Recent Advances of Crystal Engineering and Solid-State Chemistry by Professor J.J.Vittal
DESCRIPTION:In conjunction with Professor Jagadese J. Vittal’s retirement in December 2020\, the Department of Chemistry at NUS is organizing a retirement symposium\, titled “Recent Advances on Crystal Engineering and Solid-State Chemistry”\, to commemorate his 23 years in NUS Chemistry and the scientific community.  The symposium will be held online on 26 March 2021 from 9am -1pm (Singapore time).  \nKindly register for the symposium here
URL:https://chemistry.nus.edu.sg/event/recent-advances-of-crystal-engineering-and-solid-state-chemistry/
LOCATION:Online
ORGANIZER;CN="Department of Chemistry%2C NUS":MAILTO:chemistry-outreach@nus.edu.sg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20210312T100000
DTEND;TZID=Asia/Singapore:20210312T113000
DTSTAMP:20260423T005943
CREATED:20210309T063127Z
LAST-MODIFIED:20220329T072448Z
UID:5245-1615543200-1615548600@chemistry.nus.edu.sg
SUMMARY:Advancing Cancer Therapeutics by Designing Molecules in Chemistry and Biology
DESCRIPTION:Host: Professor Yao Shaoqin \nSpeaker: Dr Ru-Yi Zhu \nRu-Yi received his B.S. degree in chemistry from Peking University in 2013. His thesis\, “Transition-metal-mediated C‒O and C‒H activation reactions”\, was completed under Prof. Zhang-Jie Shi’s supervision. He obtained his doctoral degree from The Scripps Research Institute in 2018\, with Ph.D. thesis\, “Palladium-catalyzed diverse C(sp3)‒H activation reactions enabled by ligand and directing group design”\, under Prof. Jin-Quan Yu. Currently\, he is a postdoctoral research fellow in the Department of Chemistry\, ChEM-H Institute\, and Stanford Cancer Institute\, Stanford University\, working on chemical biology of DNA\, RNA\, and associated proteins for cancer therapeutics\, with Prof. Eric T. Kool. Ru-Yi’s research integrates state-of-the-art synthetic organic chemistry with molecular biology to validate therapeutic targets\, identify potential small-molecule anti-cancer drugs\, and develop molecular tools for cancer early diagnosis. \nAbstract:  \nDespite tremendous efforts and progress in combating cancer over the last few decades\, many cancers remain undiagnosable at early stage and difficult-to-treat. More than 10 million people die from cancer each year worldwide. In this talk\, I will discuss how to creatively design molecules in chemistry and biology to advance cancer therapeutics.  I will describe how to develop highly useful C‒H activation reactions by designing novel ligands and directing groups and how these synthetic methods can potentially accelerate early anti-cancer drug discovery. I will then focus on targeting an important DNA repair enzyme MUTYH for targeted cancer therapy by designing activity-based fluorescent probes and applying the probes with high-throughput screen (HTS) to identify small-molecule modulators. Lastly\, I will demonstrate how to use the probes to diagnose MUTYH-associated polyposis (MAP) which is a genetic disorder that causes a range of cancers. \nRegister here in advance using your NUS email account to attend this seminar.
URL:https://chemistry.nus.edu.sg/event/advancing-cancer-therapeutics-by-designing-molecules-in-chemistry-and-biology/
LOCATION:Online
CATEGORIES:Seminar,Invited Seminar
ORGANIZER;CN="Department of Chemistry%2C NUS":MAILTO:chemistry-outreach@nus.edu.sg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20210227T123000
DTEND;TZID=Asia/Singapore:20210227T180000
DTSTAMP:20260423T005943
CREATED:20210218T050418Z
LAST-MODIFIED:20210228T015813Z
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SUMMARY:CHS Chemistry e-Open House 2021
DESCRIPTION:Join us in the CHS Chemistry e-Open House on 27 Feb 2021 here! and find out how you can enrich your learning experiences by studying abroad\, undertaking internships or research projects\, obtaining prestigious awards\, and participating in many other learning opportunities and activities in Chemistry at NUS.
URL:https://chemistry.nus.edu.sg/event/chs-chemistry-e-open-house-2021/
LOCATION:Online
CATEGORIES:Outreach
ORGANIZER;CN="Department of Chemistry%2C NUS":MAILTO:chemistry-outreach@nus.edu.sg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20210220T100000
DTEND;TZID=Asia/Singapore:20210220T113000
DTSTAMP:20260423T005943
CREATED:20210204T092731Z
LAST-MODIFIED:20220329T072533Z
UID:4970-1613815200-1613820600@chemistry.nus.edu.sg
SUMMARY:Advancing the Frontiers of Science and Technology with Chemistry
DESCRIPTION:Wonder how exciting chemistry can be? Join our e-Research Talk\, “Advancing the frontiers of science and technology with Chemistry” held on 20 February 2021\, 10am – 11.30am on Zoom.  Our professors will share how chemistry has brought them to explore the vast natural world and create new innovations for humankind in exciting ways.  The talk is especially tailored for pre-University students.  All students and teachers are welcome. \nRegister here using your school email account by 18 February 2021\, 5pm to join the session (first come\, first served basis). \n\n  \nAbout the Speakers:\nProfessor Chua Lay-Lay \n \n\n​Professor Chua is the Assistant Head of Department Chemistry  (Graduate) and the Director of Organic Nano Device Laboratory at NUS. She received her B.Sc. degree in Chemistry from National University of Singapore. She completed her Ph.D. in Physics at the University of Cambridge in 2007.   She began her independent academic career at National University of Singapore in 2008. She serves as associate editor of Journal of Materials Chemistry C. Prior to her academic career\, she worked in Semiconductor industry in Singapore; she was a member of Technical Staff at Bell Laboratories\, Lucent Technologies\, New Jersey\, USA; Research Associate at University of Cambridge and also Research Fellow at National University of Singapore.  Her research interests focus on materials and processing development to advance the science and technology of polymer organic semiconductors including organic polymer−graphene hybrids for advanced applications in organic electronics\, polymer thermal electric generators and batteries\, and also nonlinear optics. \n  \nAssistant Professor Wu Jie \n\n \n\nDr Wu has joined the Department of Chemistry\, NUS as an assistant professor since 2015. Prior to that\, he worked as a senior scientist in Snapdragon Chemistry Inc. at Boston which is established by his postdoc advisor Prof. Timothy Jamison for half a year. He did his postdoctoral in the Department of Chemistry and Chemical Engineering at MIT\, working with Prof. Timothy Jamison and Prof. Alan Hatton. His postdoctoral research was aimed at utilizing CO2 as a green C1 source to synthesize useful chemicals in continuous flow reactors. Dr Wu was awarded the Young Scientist Award 2020 by the Faculty of Science\, NUS. His research interests have broadly and deeply involved in two research fields of organic synthesis\, including photocatalysis and continuous-flow automated synthesis. In his spare time\, Dr Wu likes to play basketball and badminton. \n  \n\n\nAssistant Professor Winston Zhao \n\n  \n \n\nDr Zhao is the second President’s Assistant Professor in the Department of Chemistry\, NUS. He received his pre-university education in Singapore\, before heading to Caltech for his undergraduate studies on the National Science Scholarship\, where he obtained double B.S. degrees with honors in Chemistry and Biology. He completed his Ph.D. in Biophysics at the Harvard University under the mentorship of Sunney Xie. Since returning to Singapore\, he has conducted postdoctoral research at the Institute of Molecular and Cell Biology and the Genome Institute of Singapore\, before joining the Department. His research focuses on the development and application of advanced imaging-based approaches to quantitatively probe the biophysical chemistry of chromatin dynamics at the single-cell level. In particular\, he is interested in understanding how molecular processes related to chromatin structure\, accessibility\, and expression are organized and regulated in space and time. By integrating approaches from optical microscopy and spectroscopy\, genome and protein engineering\, and computational analysis\, his work aims to illuminate the physico-chemical driving forces that underpin the spatio-temporal heterogeneities in chromatin dynamics\, as well as the physiological implications of their misregulation in human diseases.
URL:https://chemistry.nus.edu.sg/event/advancing-the-frontiers-of-science-and-technology-with-chemistry-2/
LOCATION:Online
CATEGORIES:Outreach
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BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20210210T110000
DTEND;TZID=Asia/Singapore:20210210T123000
DTSTAMP:20260423T005943
CREATED:20210204T073151Z
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SUMMARY:Light up the brain: How chemistry helps read and control the mind by Dr Chen Shuo
DESCRIPTION:Abstract: \nFor decades\, scientists and physicians have electrically recorded and stimulated neurons deep in the brain with implanted electrodes: The former is known as electrophysiology while the latter represents a major therapy – deep brain stimulation – that is widely used to treat patients with neurological symptoms. However\, these electrical approaches lack cell specificity and are largely invasive. The past decade has witnessed the emergence of optical methods to precisely image and modulate the activities of genetically defined neurons in vivo. In this lecture\, I will introduce two cutting-edge optical approaches\, optogenetics and in vivo imaging\, in neuroscience research. In particular I will highlight how chemistry plays an essential role in generating actuators and sensors for these neurotechnologies. \nOptogenetics harnesses genetically encoded light-gated ion channels\, the so-called rhodopsins\, to optically stimulate target neurons. Variants of rhodopsins with various kinetic and spectral parameters have been developed to activate or inhibit neurons. I will present an example to illustrate how optogenetics is used to interrogate neural circuits for learning and memory. Although optogenetics has revolutionized experimental neuroscience\, for deep brain applications it has a limitation that it requires the insertion of invasive optical fibers. I will discuss our recent work to employ upconversion nanoparticles to shift the optogenetic spectra to the near-infrared region that enables transcranial near-infrared brain stimulation. \nWhile optogenetics is used for neural modulation\, in vivo optical imaging is well applied for recording neuronal activities. Calcium and voltage indicators have been developed to probe neuronal activity\, nanoparticles have been used for tracking molecular transport in neurons\, while two-photon microscopy has enabled deep tissue imaging at a high resolution. These technical advances have allowed real-time functional imaging of neurons in behaving animals\, contributing to the understanding of cognitive processes in the brain such as how memory is encoded. \nFurther development of optical approaches for brain science will require cross-disciplinary collaborations involving chemists who develop molecular sensors and actuators. These achievements will rapidly pave the way not only to a better understanding of how the brain works but also towards a bright therapeutic future for patients with brain diseases. \nRegister here to attend the session.
URL:https://chemistry.nus.edu.sg/event/light-up-the-brain-how-chemistry-helps-read-and-control-the-mind-by-dr-chen-shuo/
LOCATION:Online
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Singapore:20210209T110000
DTEND;TZID=Asia/Singapore:20210209T120000
DTSTAMP:20260423T005943
CREATED:20210204T044018Z
LAST-MODIFIED:20220329T072510Z
UID:4941-1612868400-1612872000@chemistry.nus.edu.sg
SUMMARY:From molecular machines to brain circuits: Chemistry for reading and controlling information flow by Dr Chen Shuo
DESCRIPTION:Abstract: \nChemical biology approaches that allow for in vivo recording and modulation of neuronal activities hold the key to understanding how the brain works and developing next-generation therapies for neurological diseases. Despite significant technical progress in synthetic chemistry over the past decades\, the application of synthetic molecules and materials to reading and controlling cognition in the living brain is still in its infancy. In this talk\, I will first introduce the synthesis of a voltage-responsive molecular machine to illustrate how the state-of-the-art of synthetic chemistry has allowed us to create molecular systems whose energy conversion and logic flow can be precisely controlled. I will then show how molecularly tailored artificial actuators\, in particular upconversion nanoparticles\, can be used for non-invasive optical stimulation of specific neurons nestled deep in the brain. This technology\, called NIR upconversion optogenetics\, has allowed for transcranial modulation of various brain functions\, such as evoking dopamine release\, inducing brain oscillations\, and triggering memory recall. Finally\, I will share an example to demonstrate the power of chemical biology approaches\, in particular optogenetics and tissue-clearing technologies\, in making fundamental neuroscience discoveries when combined with physiological and behavioral experiments. Tagging and manipulation of defined neurons have allowed us to identify a previously unknown novelty hub in the mammalian brain that plays an essential role in memory modulation. Collectively\, these works shed light on a new avenue of chemical biology that aims at cutting-edge applications in neuroscience\, ranging from probing how the brain works at molecular and systems levels to modulating brain activities for potential neurological therapies. \nRegister here to attend the session. 
URL:https://chemistry.nus.edu.sg/event/from-molecular-machines-to-brain-circuits-chemistry-for-reading-and-controlling-information-flow-by-dr-chen-shuo/
LOCATION:Online
CATEGORIES:Seminar,Invited Seminar
ORGANIZER;CN="Department of Chemistry%2C NUS":MAILTO:chemistry-outreach@nus.edu.sg
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