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X-WR-CALDESC:Events for NUS Chemistry
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TZID:Asia/Singapore
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TZOFFSETFROM:+0800
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DTSTART:20200101T000000
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DTSTART;TZID=Asia/Singapore:20210312T100000
DTEND;TZID=Asia/Singapore:20210312T113000
DTSTAMP:20260417T232608
CREATED:20210309T063127Z
LAST-MODIFIED:20220329T072448Z
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SUMMARY:Advancing Cancer Therapeutics by Designing Molecules in Chemistry and Biology
DESCRIPTION:Host: Professor Yao Shaoqin \nSpeaker: Dr Ru-Yi Zhu \nRu-Yi received his B.S. degree in chemistry from Peking University in 2013. His thesis\, “Transition-metal-mediated C‒O and C‒H activation reactions”\, was completed under Prof. Zhang-Jie Shi’s supervision. He obtained his doctoral degree from The Scripps Research Institute in 2018\, with Ph.D. thesis\, “Palladium-catalyzed diverse C(sp3)‒H activation reactions enabled by ligand and directing group design”\, under Prof. Jin-Quan Yu. Currently\, he is a postdoctoral research fellow in the Department of Chemistry\, ChEM-H Institute\, and Stanford Cancer Institute\, Stanford University\, working on chemical biology of DNA\, RNA\, and associated proteins for cancer therapeutics\, with Prof. Eric T. Kool. Ru-Yi’s research integrates state-of-the-art synthetic organic chemistry with molecular biology to validate therapeutic targets\, identify potential small-molecule anti-cancer drugs\, and develop molecular tools for cancer early diagnosis. \nAbstract:  \nDespite tremendous efforts and progress in combating cancer over the last few decades\, many cancers remain undiagnosable at early stage and difficult-to-treat. More than 10 million people die from cancer each year worldwide. In this talk\, I will discuss how to creatively design molecules in chemistry and biology to advance cancer therapeutics.  I will describe how to develop highly useful C‒H activation reactions by designing novel ligands and directing groups and how these synthetic methods can potentially accelerate early anti-cancer drug discovery. I will then focus on targeting an important DNA repair enzyme MUTYH for targeted cancer therapy by designing activity-based fluorescent probes and applying the probes with high-throughput screen (HTS) to identify small-molecule modulators. Lastly\, I will demonstrate how to use the probes to diagnose MUTYH-associated polyposis (MAP) which is a genetic disorder that causes a range of cancers. \nRegister here in advance using your NUS email account to attend this seminar.
URL:https://chemistry.nus.edu.sg/event/advancing-cancer-therapeutics-by-designing-molecules-in-chemistry-and-biology/
LOCATION:Online
CATEGORIES:Seminar,Invited Seminar
ORGANIZER;CN="Department of Chemistry%2C NUS":MAILTO:chemistry-outreach@nus.edu.sg
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