Assistant Professor Wu Jie




B.Sc., Beijing Normal University, 2006; Ph.D, Boston University, 2012; Postdoctoral, Massachusetts Institute of Technology, 2012-2015.

Contact Information

Office: S15-05-02
Tel: (65)-6516-1020 | Fax: (65)-6779-1691
Email: chmjie@nus.edu.sg | Personal webpage


 

ORCID: 0000-0002-9865-180X
ResearcherID: C-5504-2016

 

Recognition and Achievements

  • SkolTech Postdoctoral Fellow, Massachusetts Institute of Technology, 2013-2014

 

Research Interests

The research program in WU group will leverage recent advances in organic synthesis with continued development of engineered continuous-flow reactors to provide new chemical transformations and technologies with relevance to contemporary problems. The field of flow chemistry is rapidly expanding and has the potential to revolutionize the synthesis of organic molecules. It has also been identified as a key research area for sustainable manufacturing in industry. Our long-term goal is to advance otherwise difficult or ineffective chemical reactions using continuous-flow techniques, as well as to develop new chemical strategies to aid the multistep flow process. Our group’s research is truly multidisciplinary including both organic chemistry and engineering aspects, which provides opportunities to learn areas of research outside of traditional organic synthesis. Students in my group will get trained on continuous-flow synthesis, multistep synthesis, green chemistry, and microfluidics. They will build in-depth chemistry background and strong problem-solving techniques. The advantages of continuous flow processing are increasingly being appreciated both by industry and academia, and students expertized in this field will find enormous job opportunities.

 

Teaching Contributions

  • CM2121 Organic Chemistry 2
  • CM5221 Advanced Organic Synthesis

 

Representative Publications 

  • Wu, J.; Yang, X., He, Z.; Mao, X.; Hatton, T. A.; Jamison, T. F. Continuous Flow Synthesis of Ketones from Carbon Dioxide and Organolithium or Grignard Reagents. Angew. Chem. Int. Ed. 2014, 53, 8416-8420.
  • Wu, J.; Kozak, J. A.; Simeon, F.; Hatton, T. A.; Jamison, T. F. Mechanism-Guided Design of Flow Systems for Multicomponent Reactions: Conversion of CO2 and Olefins to Cyclic Carbonates. Chem. Sci. 2014, 5, 1227-1231.
  • Kozak, J. A.; Wu, J.; Su, X.; Simeon, F.; Hatton, T. A.; Jamison, T. F. Bromine-Catalyzed Conversion of CO2 and Epoxides to Cyclic Carbonates under Continuous Flow Conditions. J. Am. Chem. Soc. 2013, 135, 18497-18501.
  • Wu, J.; Pu, Y.; Panek, J. S. Divergent Synthesis of Functionalized Carbocycles through Organosilane-Directed Asymmetric Alkyne-Alkene Reductive Coupling and Annulation Sequence. J. Am. Chem. Soc. 2012, 134, 18440-18446.
  • Wu, J.; Becerril, J.; Lian, Y. J.; Davies, H. M. L.; Porco, J. A.; Panek, J. S. Sequential Transformations to Access Polycyclic Chemotypes: Asymmetric Crotylation and Metal Carbenoid Reactions. Angew. Chem. Int. Ed. 2011, 50, 5938-5942.
  • Wu, J.; Panek, J. S. Total Synthesis of (-)-Virginiamycin M-2. Angew. Chem. Int. Ed. 2010, 49, 6165-6168.