Assistant Professor Wu Jie

photo of Dr Wu Jie

Personal Web Page

Postdoc, 2012-2015, MIT; Ph.D, 2012, Boston University; B.Sc., 2006, Beijing Normal University

Contact Information

Department of Chemistry, NUS
3 Science Drive 3
Singapore 117543

Office: S15-05-02
Tel: (65)-6516-1020
Fax: (65)-6779-1691



We are having multiple openings available on Ph.D. and postdoc levels. Self-motivated chemists with strong background and experience in organic synthesis are encouraged to apply for the postdoc openings. Students who are interested in organic synthesis, continuous-flow synthesis, and green chemistry are welcome to apply for the Ph.D. openings. Please send an electronic copy of your curriculum vitae, research summary and references contact information to


Research Interests

Organic Synthesis, Continuous-Flow Synthesis, Green Chemistry, Microfluidic

The research program in my group will leverage recent advances in organic synthesis with continued development of engineered continuous-flow reactors to provide new chemical transformations and technologies with relevance to contemporary problems. The field of flow chemistry is rapidly expanding and has the potential to revolutionize the synthesis of organic molecules. It has also been identified as a key research area for sustainable manufacturing in industry. Our long-term goal is to advance otherwise difficult or ineffective chemical reactions using continuous-flow techniques, as well as to develop new chemical strategies to aid the multistep flow process.

Our group’s research is truly multidisciplinary including both organic chemistry and engineering aspects, which provides opportunities to learn areas of research outside of traditional organic synthesis. Students in my group will get trained on continuous-flow synthesis, multistep synthesis, green chemistry, and microfluidics. They will build indepth chemistry background and strong problem-solving techniques. The advantages of continuous flow processing are increasingly being appreciated both by industry and academia, and students expertized in this field will find enormous job opportunities.

Representative Publications

  • Wu, J.; Yang, X. Q.; He, Z.; Mao, X. W.; Hatton, T. A.; Jamison, T. F. “Continuous Flow Synthesis of Ketones from Carbon Dioxide and Organolithium or Grignard Reagents” Angew. Chem. Int. Ed. 2014, 53, 8416-8420. (Featured by Synfacts 2014, 10, 1191)
  • Wu, J.; Kozak, J. A.; Simeon, F.; Hatton, T. A.; Jamison, T. F. “Mechanism-Guided Design of Flow Systems for Multicomponent Reactions: Conversion of CO2 and Olefins to Cyclic Carbonates” Chem. Sci. 2014, 5, 1227-1231.
  • Kozak, J. A.*; Wu, J.*; Su, X.; Simeon, F.; Hatton, T. A.; Jamison, T. F. “Bromine-Catalyzed Conversion of CO2 and Epoxides to Cyclic Carbonates under Continuous Flow Conditions” J. Am. Chem. Soc. 2013, 135, 18497-18501(*Co-first author).
  • Wu, J.; Pu, Y.; Panek, J. S. “Divergent Synthesis of Functionalized Carbocycles through Organosilane-Directed Asymmetric Alkyne-Alkene Reductive Coupling and Annulation Sequence” J. Am. Chem. Soc. 2012, 134, 18440-18446.
  • Wu, J.; Zhu, K.; Yuan, P.; Panek, J. S. “Bifunctional Homoallylic Carbamates from Chiral Silane Additions to in Situ Generated N-Acyl Iminium Ions” Org. Lett. 2012, 14, 3624-3627.
  • Wu, J.; Panek, J. S. “Total Synthesis of (-)-Virginiamycin M2: Application of Crotylsilanes Accessed by Enantioselective Rh(II) or Cu(I) Promoted Carbenoid Si-H Insertion” J. Org. Chem. 2011, 76, 9900-9918 (Featured Article).
  • Wu, J.; Becerril, J.; Lian, Y.; Davies, H. M. L.; Porco, J. A. Jr.; Panek, J. S. “Sequential Transformations to Access Polycyclic Chemotypes: Asymmetric Crotylation and Metal Carbenoid Reactions” Angew. Chem. Int. Ed. 2011, 50, 5938-5942.
  • Wu, J.; Panek, J. S. “Total Synthesis of (-)-Virginiamycin M2” Angew. Chem. Int. Ed. 2010, 49,6165-6168.(Featured by Synfacts 2010, 11, 1219 and Organic Chemistry Portal 2010. Most accessed paper in Angew. Chem. Int. Ed.).
  • Wu, J.; Chen, Y.; Panek, J. S. “Vinylogous Aldol Products from Chiral Crotylsilanes Obtained by Enantioselective Rh(II) and Cu(I) Carbenoid Si-H Insertion” Org. Lett. 2010, 12, 2112-2115 (Featured by Synfacts 2010, 8, 914).